Oxidation effects on tetrahydropterin metabolism.
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Oxidation effects on tetrahydropterin metabolism.

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Published by Aston University. Department of Pharmaceutical Sciences in Birmingham .
Written in English


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Thesis (PhD) - Aston University, 1987.

ID Numbers
Open LibraryOL13877145M

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Tetrahydrobiopterin is a naturally occurring nutrient and an essential cofactor of enzymes involved in the biosynthesis of 5-hydroxytryptamine (5-HT, serotonin), dopamine, noradrenaline (norepinephrine), adrenaline (epinephrine), melatonin, and nitric oxide (6 R). The enzymes for which it is a cofactor include tryptophan hydroxylase, phenylalanine hydroxylase, tyrosine hydroxylase, nitric oxide synthase, and glyceryl ether monooxygenase.   The effects of 6R-5,6,7,8-tetrahydro-L-biopterin (6A-BH 4), the in vivo cofactor for tryptophan hydroxylase, on the synthesis, release, and metabolism of serotonin were studied in superfused slices from rat by: Isolation and characterization of tetrahydropterin oxidation products generated in the tyrosine 3-monooxygenase (tyrosine hydroxylase) reaction. European Journal of Biochemistry , (1), DOI: /jtbx. Jan HAAVIK, Anne P. DOSKELAND, Torgeir by: from book Physician's Guide to the Laboratory Diagnosis of Metabolic Diseases (pp) Disorders of Phenylalanine and Tetrahydrobiopterin Metabolism Chapter January with 45 Reads.

Title: Disorders of Tetrahydrobiopterin Metabolism and their Treatment VOLUME: 3 ISSUE: 2 Author(s):H. Shintaku Affiliation:Department of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-machi, Abeno-ku, Osaka , Japan Keywords:Tetrahydrobiopterin metabolism, Gtp cyclohydrolase I deficiency, 6-pyruvoyl-tetrahydropterin synthase deficiency, . Oxidation- Reduction Reactions Oxidation Numbers Types of Chemical Reactions Voltaic Cells Review Skills The presentation of information in this chapter assumes that you can already perform the tasks listed below. You can test your readiness to proceed by answering the Review Questions at the end of the Size: 1MB. Lipid metabolism. The importance of oxygen in functional oxidative phosphorylation leads to a significant reduction in ATP production from the beta-oxidation of fatty acids that is proportional to the degree of ischemia. In mild to moderate ischemia, the rate of fatty acid oxidation decreases but still fuels oxidative by: 3. In its effects on metabolism, epinephrine acts primarily on muscle, adipose tissue, and liver. It activates glycogen phosphorylase and inactivates glycogen synthase (by cAMP-dependent phosphorylation of the enzymes; see Fig. and p. ), thus stimulating the conversion of liver glycogen into blood glucose, the fuel for anaerobic muscular.

Chapter 17 Amino Acid Oxidation and the Production of Urea. Amino acids, derived largely from protein in the diet or from degradation of intracellular proteins, are the final class of biomolecules whose oxidation makes a significant contribution to the generation of metabolic energy. Tetrahydrobiopterin, also known as sapropterin, is a cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine, epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced Pregnancy category: US: C (Risk not ruled out).   Phenylalanine hydroxylase can catalyze the oxidation of its tetrahydropterin cofactor without concomitant substrate hydroxylation. We now report that this "uncoupled" tetrahydropterin oxidation is mechanistically distinct from normal enzyme by: Tetrahydrobiopterin (BH4) deficiencies are disorders affecting phenylalanine metabolism in liver and neurotransmitters biosynthesis in brain. BH4 is the essential cofactor in the enzymatic.